LeXso EMS Panel v1.0
- #LX11502
- #LX11501
The LeXso EMS Panel v1.0 (Early Methylation for Screening) is a high-performance epigenetic profiling solution designed for the early detection and monitoring of nine high-incidence cancers. By targeting a highly curated set of 76 candidate genes and over 2,000 specific CpG sites, this panel provides a panoramic view of the methylation landscape associated with both carcinogenesis and tumor suppression.
Comprehensive Multi-Cancer Coverage
The LeXso EMS Panel v1.0 targets a strategic 20 Kb genomic footprint, incorporating methylation sites approved by the NMPA and FDA, alongside those rigorously validated in leading scientific literature and patents. This panel enables the simultaneous screening of nine major cancer types:
- Respiratory & Digestive: Lung, Colorectal, Gastric, and Liver cancer.
- Reproductive & Urological: Breast, Prostate, Cervical, and Ovarian cancer.
- Specialized Screening: Bladder cancer.
- Product Details
- Kit Content
- FAQ
- Ordering Information
- Resources
Integrated Multi-Cancer Detection
- Analyze CpG sites across multiple genes for nine major cancer types within a single, high-efficiency assay.
Broad Sample Compatibility
- Optimized for high-performance results across diverse sample types, including circulating cell-free DNA (cfDNA), genomic DNA (gDNA), and varying grades of Formalin-Fixed Paraffin-Embedded (FFPE) tissue.
Accurate Methylation Quantification
- Achieve precise, absolute quantification of methylation levels, essential for identifying the subtle epigenetic shifts found in early-stage malignancies.
High-Efficiency Capture Kinetics
- When combined with the LeXso Total Solution for Methylation, the panel ensures uniform data quality, superior capture efficiency, and exceptional stability across runs.
Flexible Panel Customization
- Scale your research by customizing panels with different gene sets or CpG site densities to target specific single or multi-cancer combinations.
| Species of Cancer | Biomarker |
| Lung Cancer | SCT、HOXA7、RASSF1、SHOX2、PTGER4 |
| Colorectal Cancer | NDRG4、BCAT1、Septin9、BMP3、TFPI2、SDC2、SFRP2 |
| Gastric Cancer | Septin9、RNF180、TCF4、RPRM、SDC2、TERT |
| Liver Cancer | SCN4B、BDH1、HOXA10、PLAC8、BMPR1A、TEPP、SPACA6、MIXL1、TSC22D1 |
| Breast Cancer | CDO1、PITX2、GSTP1、GP5、APC |
| Bladder Cancer | SOX1、GALR1、DMRTA2、EVX2、SOX17、DCHS2、TWIST1、TBX5、HOXA11、SIM2、LHX2 |
| Prostatic Cancer | CCND2、CDH1、MCAM、PENK、PITX2、PTGS2、RARB、LINC02028、SLCO3A1、HES5、TPM4、FHAD1、SOX1-OT、IGFBP3、ZNF154、FEZF2、APC |
| Cervical Cancer | SOX1、PAX1、JAM3、TAFA4、ASTN1、DLX1、ITGA4、RXFP3、SOX17 |
| Ovarian Cancer | PCDHB18P、CDO1、HOXA9、LYPD5、CDH13、FOXD3、ZNF671、HOXA11、FBXO32、OPCML、BLACAT1、LRRC41、GNE、FAIM2、CAPN2、SIM2 |
| Catalog | Color Of Tube Cap | Component | Volume | Package/Storage |
| LX11502 | ● | LeXso EMS Panel v1.0, 16 rxn | 40 μL | -20℃ |
| LX11501 | ● | LeXso EMS Panel v1.0, 96 rxn | 210 μL | -20℃ |
Early methylation signals in liquid biopsies are often found in ultra-trace amounts of cfDNA. Our probe design and optimized hybridization buffers are specifically tuned to maximize capture efficiency for fragmented DNA, ensuring high signal-to-noise ratios even when the circulating tumor DNA (ctDNA) fraction is low.
Yes. By targeting 76 different genes across 2,000+ CpG sites, the panel provides a multi-marker methylation signature. Our associated bioinformatics pipelines analyze these signatures to help researchers identify tissue-specific methylation patterns associated with the nine high-incidence cancers covered by the panel.
Absolutely. For the best results, we recommend using the LeXPrep Methyl Library Preparation Kit v2 for library construction. This integration ensures that the library complexity is maintained throughout the conversion process, providing the high-fidelity input needed for the LeXso EMS targeted capture.
DNA methylation changes often occur earlier than traditional genetic mutations in many cancers. By focusing on these early epigenetic markers, the LeXso EMS Panel provides a powerful tool for researchers looking to develop early screening assays and improve the detection limits of liquid biopsy platforms.
| Product | Catalog |
|---|---|
| LeXso EMS Panel v1.0, 16 rxn | LX11502 |
| LeXso EMS Panel v1.0, 96 rxn | LX11501 |
For inquiries or to request a formal quotation, please contact us at support@lexigenbio.com