LeXPress Hybrid Capture Reagents
- #LX05402
- #LX05401
LeXPress Hybrid Capture Reagents: High-Velocity Target Enrichment
The LeXPress Hybrid Capture Reagents system is a next-generation solution optimized for rapid, high-performance target enrichment. Engineered to streamline the liquid-phase hybridization workflow, LeXPress provides researchers with the flexibility to balance speed and data depth without compromising on capture quality.
A Complete Capture Ecosystem
The LeXPress system is designed to work in perfect synergy with the LeXPrep Blocker series and our 120 nt Panel/Probe portfolios. This integrated chemistry ensures efficient binding kinetics and exceptional on-target rates across a wide range of genomic targets.
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- Single-Buffer Simplification: By consolidating elution buffers into a single, optimized reagent, LeXPress reduces the complexity of the workflow, significantly minimizing the risk of manual pipetting errors.
- Automation-First Architecture: The streamlined protocol is specifically designed for high-throughput labs, facilitating easy integration with automated liquid-handling systems like the LeXBot series for a truly hands-off experience.
- Protocol Flexibility: Choose the workflow that fits your project. Support for both Rapid Hybridization (0.5–4 hours) for urgent clinical turnarounds and Standard Overnight Hybridization (16 hours) for maximum sensitivity.
- Performance Optimization: Easily adjust hybridization duration to fine-tune performance based on panel size, sample type, or sequencing depth requirements.
In modern genomics, time-to-insight is critical. LeXPress removes the traditional bottlenecks of hybridization capture. By simplifying the chemistry and accelerating the kinetics, it allows laboratories to deliver high-quality sequencing data faster, more reliably, and with fewer operational hurdles.
| Package | Color Of Tube Cap | Component | Volume (16 rxn) | Volume (96 rxn) |
| Box 1 | ● | Xpress Hyb #1 | 380 μL | 2×1150 μL |
| ● | Hyb #2 | 120 μL | 720 μL | |
| ● | Human Cot DNA | 110 μL | 650 μL | |
| / | Xpress Wash Buffer | 4×4 mL | 5×19 mL | |
| ● | Sealing Oil | 250 μL | 1.5 mL | |
| Box 2 | / | Streptavidin Beads | 950 μL | 5.7 mL |
While LeXPress is optimized for our 120 nt probes and Blocker series, its robust buffer chemistry is compatible with most standard biotinylated probe sets. However, for maximum fold-80 enrichment and uniformity, we recommend the complete LeXPress ecosystem.
Our rapid protocol is specifically formulated to maintain high sensitivity. For most standard panels, a 2-hour hybridization with LeXPress yields results comparable to traditional overnight methods. For extremely large panels or low-input samples, the protocol can be easily extended to optimize performance.
Automation thrives on simplicity. By reducing the number of reagent changes and wash steps, the single-buffer system decreases the number of deck positions required and simplifies the programming of liquid-handling robots, leading to more robust and repeatable automated runs.
| Product | Catalog |
|---|---|
| LeXPress Hybrid Capture Reagents, 16 rxn | LX05402 |
| LeXPress Hybrid Capture Reagents, 96 rxn | LX05401 |
For inquiries or to request a formal quotation, please contact us at support@lexigenbio.com