LeXOnCT Panel
- #LX01902
- #LX01901
LeXOnCT Panel: High-Efficiency Liquid Biopsy & Solid Tumor Profiling
The LeXOnCT Panel is a versatile, compact targeted enrichment solution specifically engineered for the high-sensitivity analysis of solid tumors and liquid biopsies. By focusing on a highly curated set of 69 essential genes, this panel delivers the deep, uniform coverage required for the accurate detection of low-frequency variants in both tissue and blood-based samples.
Optimized for Multi-Sample Versatility
The LeXOnCT system is designed to overcome the unique challenges associated with diverse sample types:
- Liquid Biopsy (cfDNA): Advanced probe architecture enables the high-fidelity detection of ultra-trace circulating tumor DNA (cfDNA), making it an ideal tool for non-invasive monitoring.
- Tissue Profiling (FFPE): Optimized chemistry ensures robust performance and consistent enrichment from Formalin-Fixed Paraffin-Embedded (FFPE) samples, even when DNA is fragmented or limited.
Streamlined Workflow
LeXOnCT integrates seamlessly with the LeXPress hybrid capture system and LeXBot automation series, providing a rapid, reproducible path from sample to insight for longitudinal studies and clinical research.
- Product Details
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- Precision Gene Curation: Targets 69 of the most clinically relevant genes in oncology, providing focused insights into the mutational landscape without the cost or data overhead of larger exome-scale panels.
- Exceptional Uniformity: Our optimized probe design ensures highly uniform coverage across all targeted regions, minimizing sequencing waste and increasing the sensitivity of variant calling.
- High-Depth Sequencing: The compact 69-gene footprint allows for ultra-high-depth sequencing, essential for identifying subclonal mutations and monitoring minimal residual disease (MRD).
Genes with coding regions covered
| AKT1 | ALK | APC | AR | ARAF | ATM | BRAF | BRCA1 | BRCA2 | CCND1 |
| CDH1 | CDK12 | CDK4 | CDK6 | CDKN2A | CTNNB1 | DDR2 | EGFR | ERBB2 | ERCC2 |
| ESR1 | EZH2 | FGFR1 | FGFR2 | FGFR3 | GNA11 | GNAQ | GNAS | HRAS | IDH1 |
| IDH2 | JAK2 | JAK3 | KDM6A | KIT | KRAS | MAP2K1 | MAP2K2 | MDM2 | MET |
| MLH1 | MPL | MSH2 | MSH6 | MTOR | MYC | NF1 | NPM1 | NRAS | NTRK1 |
| NTRK2 | NTRK3 | PDGFRA | PIK3CA | PMS2 | PTCH1 | PTEN | PTPN11 | RAF1 | RB1 |
| RET | ROS1 | SMARCB1 | SMO | STK11 | TERT | TP53 | TSC1 | TSC2 |
Genes with full coding regions shown in bold.
Genes with selected introns covered
| ALK | BRAF | EGFR | FGFR2 | FGFR3 | MET | NTRK1 | NTRK2 | PDGFRA | RET | ROS1 |
Microsatellite Markers
| BAT-25 | BAT-26 | BAT-40 | BAT-RII | NR-21 | NR-22 | NR-24 | NR-27 | MONO-27 |
| D2S123 | D5S346 | D17S261 | D17S520 | D18S34 |
| Package | Color Of Tube Cap | Component | Volume | Package/Storage |
| LX01902 | ● | LeXOnCT Panel, 16 rxn | 70 μL | -20℃ |
| LX01901 | ● | LeXOnCT Panel, 96 rxn | 415 μL | -20℃ |
While the LeXOnco Plus Panel (637 genes) provides a broad view for Comprehensive Genomic Profiling (CGP), the LeXOnCT Panel is designed for speed and depth. By focusing on 69 core genes, it allows for significantly higher sequencing depth at a lower cost, which is critical for detecting low-frequency mutations in liquid biopsy samples.
Yes. Its high sensitivity in cfDNA and compact design make it a cost-effective and reliable solution for tracking tumor dynamics, assessing treatment response, and identifying the emergence of resistance mutations over time.
The panel is optimized for high-sensitivity detection of Single Nucleotide Variants (SNVs) and small Insertions/Deletions (Indels). Due to its high uniformity, it also supports the analysis of focal Copy Number Variations (CNVs) in targeted regions.
| Product | Catalog |
|---|---|
| LeXOnCT Panel v1.0, 16 rxn | LX01902 |
| LeXOnCT Panel v1.0, 96 rxn | LX01901 |
For inquiries or to request a formal quotation, please contact us at support@lexigenbio.com