LeXOncofusion (for RNA) Panel

Targeted Precision for Solid Tumors

The panel focuses on 105 high-impact genes curated for their high clinical relevance and frequent involvement in oncogenic fusions. To ensure no critical data is missed, the probe design offers exhaustive coverage across:

• Transcript Coding Regions (CDS): Complete enrichment of all coding sequences as defined by RefSeq 109.
• Strategic UTR Coverage: Targeted inclusion of critical Untranslated Regions (UTRs) where fusion breakpoints and regulatory disruptions frequently occur.

Triple-Layer Data Insights in a Single Assay

The LeXOncoFu system enables researchers to extract multidimensional information from a single RNA sample, maximizing data yield from often-limited clinical specimens:

1. Fusion Detection: Definitively identify known and novel fusion events with their specific partner genes and isoforms.
2. Expressed Mutation Analysis: Detect single nucleotide variants (SNVs) and indels within active transcripts to assess the functional mutation load.
3. Gene Expression Profiling: Quantify transcript abundance to identify signature patterns of oncogenic transformation and pathway activation.

*Covers all 5′-UTRs; †Covers all 3′-UTRs。