LeXOnco Plus Panel
- #LX01112F
- #LX01111F
LeXOnco Plus Panel: Comprehensive Solid Tumor Profiling
The LeXOnco Plus Panel is a sophisticated targeted enrichment solution designed for in-depth genomic profiling in solid tumor research. Spanning an expansive 2.4 Mb target region, this panel provides a holistic view of the cancer genome by integrating genetic, structural, and pharmacogenomic markers into a single, high-efficiency workflow.
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Expansive Genomic Coverage
The panel targets a total of 637 genes, providing exhaustive coverage of:
- Coding Regions: Full CDS enrichment for 620 key oncogenes and tumor suppressors.
- Immune Profiling: Includes highly polymorphic HLA genes to support immunotherapy research.
- Structural Landmarks: Strategically designed probes cover critical intronic regions associated with common gene fusions and rearrangements.
- Functional Markers: Includes classical microsatellite sequences for MSI (Microsatellite Instability) assessment and chemotherapy-associated polymorphic loci for pharmacogenomic insights.
Multi-Modal Variant Detection
LeXOnco Plus Panel is engineered for the simultaneous detection of diverse variant types, ensuring no critical mutation is overlooked:
- SNVs & Indels: High-sensitivity detection of base substitutions and small insertions/deletions.
- Copy Number Variations (CNVs): Robust analysis of gene amplifications and deletions.
- Structural Variants: Precise identification of gene fusions and rearrangements.
- Genomic Instability: Comprehensive evaluation of Microsatellite Instability (MSI) status.
Optimized for Clinical Research
By capturing the complete landscape of solid tumor mutations—from standard coding variants to complex fusions and chemotherapy-related markers—the LeXOnco Plus Panel empowers researchers with the comprehensive data required to advance personalized oncology and therapeutic discovery.
| Package | Color Of Tube Cap | Component | Volume | Package/Storage |
| LX01112F | ● | LeXOnco Plus Panel, 16 rxn | 70 μL | -20℃ |
| LX01111F | ● | LeXOnco Plus Panel, 96 rxn | 415 μL | -20℃ |
The LeXOnco Plus Panel is a powerful, high-performance alternative to TSO500, offering even broader genomic insight. While TSO500 covers 523 genes, the LeXOnco Plus Panel expands this to 637 genes, including highly polymorphic HLA loci essential for modern immunotherapy research. Like TSO500, our panel enables comprehensive variant detection (SNVs, Indels, CNVs, and Fusions) and provides precise calculation of pan-cancer biomarkers such as TMB and MSI. Furthermore, it is fully optimized for the LeXBot automation series, offering superior workflow flexibility and scalability.
Yes. The LeXOnco Plus Panel is a robust solution for Comprehensive Genomic Profiling (CGP). Its 2.4 Mb footprint and 637-gene content provide the necessary depth and breadth to accurately assess key pan-cancer biomarkers, including Tumor Mutational Burden (TMB) and Microsatellite Instability (MSI). By consolidating multi-modal detection into a single assay, it serves as an ideal platform for high-performance oncology research.
Yes. The panel is optimized for high-performance enrichment from a variety of sources, including FFPE tissue and ultra-low input samples, maintaining exceptional on-target rates and coverage uniformity even with degraded DNA.
While primarily designed for solid tumor tissue, the high sensitivity and deep coverage of the LeXOnco Plus Panel make it a powerful tool for detecting circulating tumor DNA (ctDNA) when paired with appropriate high-depth sequencing protocols.
| Product | Catalog |
|---|---|
| LeXOnco Plus Panel v3.0, 16 rxn | LX01112F |
| LeXOnco Plus Panel v3.0, 96 rxn | LX01111F |
For inquiries or to request a formal quotation, please contact us at support@lexigenbio.com